Metformin and Rapamycin Rejuvenate Stem Cells in Mice
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https://onlinelibrary.wiley.com/doi/10.1111/acel.13802
The aging intestine is more prone to gastrointestinal problems and colorectal cancer due to stem cell exhaustion. In this study, researchers used single-cell RNA sequencing to explore the transcriptional profile of aging intestinal stem cells and found that rapamycin and metformin can bring them to a more youthful state, reversing age-related deficits in the function and structure of the intestinal epithelium.
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Wonder when we will have data for humans